RNA周转：加尾带来的意外后果。
RNA turnover: unexpected consequences of being tailed.
作者信息
Anderson James T
机构信息
Department of Biological Sciences, Marquette University, PO Box 1881, Milwaukee, Wisconsin 53201, USA.
出版信息
Curr Biol. 2005 Aug 23;15(16):R635-8. doi: 10.1016/j.cub.2005.08.002.
PMID:16111937
Abstract
In eukaryotic cells, the 3' poly(A) tails found on mRNA influence their stability and translation. The discovery of a second nuclear poly(A) polymerase complex has fueled a series of reports defining a new and unexpected role for 3' end poly(A) tails in the nuclear surveillance and turnover of noncoding RNAs and intergenic mRNAs of unknown function.
摘要
在真核细胞中，信使核糖核酸（mRNA）上的3' 聚腺苷酸（poly(A)）尾会影响其稳定性和翻译过程。第二种核聚腺苷酸聚合酶复合物的发现引发了一系列报告，这些报告确定了3' 末端聚腺苷酸尾在非编码RNA以及功能未知的基因间mRNA的核监测和周转中发挥的新的、意想不到的作用。
Zotero 插件