Sicart R, Sable-Amplis R, Agid R
C R Seances Soc Biol Fil. 1979;173(5):937-43.
The effects of an apple-supplemented diet on plasma and liver cholesterol were investigated in two strains of Hamster, a normal one and another which exhibits a spontaneous accumulation of cholesteryl esters in the liver (FEC animals). Adding of apples to the standard diet promoted a 20 % decrease of cholesterolemia in normal animals and normalized the high level of plasma cholesterol in the FEC animals. Similarly, the cholesterol content of the liver was diminished. The levels of cholesteryl esters were strongly lowered, threefold and tenfold respectively in normal and in FEC animals. Incorporation of labelled mevalonate into cholesterol was increased, but esterification of the neosynthesized sterol was markedly reduced in the liver from FEC animals. In human daily ingestion of apples caused a significative reduction (16 %) of cholesterolemia.
在两种品系的仓鼠中研究了补充苹果的饮食对血浆和肝脏胆固醇的影响，一种是正常仓鼠，另一种是肝脏中会自发积累胆固醇酯的仓鼠（FEC动物）。在标准饮食中添加苹果可使正常动物的胆固醇血症降低20%，并使FEC动物的高血浆胆固醇水平恢复正常。同样，肝脏中的胆固醇含量也有所减少。胆固醇酯水平大幅降低，正常动物和FEC动物分别降低了三倍和十倍。FEC动物肝脏中标记的甲羟戊酸掺入胆固醇的量增加，但新合成固醇的酯化明显减少。在人类中，每日食用苹果可使胆固醇血症显著降低（16%）。
