[Interrelation of the changes in the lipid composition of the blood serum and of subcellular liver fractions as affected by an atherogenic diet].

The blood serum of white rats kept on atherogenic diet for 7 days did not show any changes as regards the correlation of lipids separated by thin-layer chromatography. Significantly reduced was only the proportion of phospholipids. Liver cell mitochondria demonstrated an increase in the relative content of cholesterol esters but a lowering of the content of triglycerides and free cholesterol. The microsomes demonstrated an increase in the relative content of cholesterol esters with a decline in the content of free fatty acids. Of cholesterol esters, the rise in the percentage of cholesteryl oleate and cholesterol esters with saturated fatty acids was proportional both in the blood serum and subcellular fractions of the liver. Fourteen and 28 days after keeping the animals on the atherogenic diet these changes became more manifest. The blood serum showed a decrease in the content of cholesteryl arachidonate with no changes in the content of cholesteryl linoleate. At the same time there was no parallelism in the changes in the content of cholesteryl arachidonate and cholesteryl linoleate in the blood serum, mitochondria or microsomes of liver cells. It is concluded that the changes in the liver lipid composition may be characterized most precisely by the relative content of blood serum cholesteryl oleate and cholesterol esters with saturated fatty acids.