Cajucom C C, Barrios G G, Cruz L, Varin C, Herrera L
Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York.
Dis Colon Rectum. 1992 Jul;35(7):676-80. doi: 10.1007/BF02053759.
From May 1988 to May 1990, a prospective autopsy study was performed in patients who died at the Philippine General Hospital in Manila, Philippines. Patients younger than 10 years of age, patients with a history of large bowel resection, and patients whose deaths were related to trauma were excluded. There were 416 patients; 246 were males, and 170 were females. The mean age was 47 years (range, 11-95 years). Six of the 416 patients (1.4 percent) were found to have polyps. One patient had an inflammatory polyp, one was diagnosed with familial adenomatous polyposis, and one had an associated cecal carcinoma. Five "sporadic" adenomatous polyps were found in the remaining three patients (prevalence rate, 0.7 percent). All of the adenomatous polyps were located distal to the hepatic flexure and exhibited only mild atypia. The mean size was 6.4 mm (range, 2-20 mm). The incidence of colorectal adenomas in Filipinos is low compared with that in age-adjusted Western populations. This finding coincides with a low incidence of colorectal carcinoma. The documentation of a low risk for adenomatous polyps and colorectal cancer indicates that it would be difficult for massive screening programs to demonstrate a significant positive impact on the early detection of colorectal neoplasias in the Filipino general population.
1988年5月至1990年5月，对在菲律宾马尼拉市菲律宾总医院死亡的患者进行了一项前瞻性尸检研究。排除了10岁以下的患者、有大肠切除术病史的患者以及死亡与创伤相关的患者。共有416例患者，其中男性246例，女性170例。平均年龄为47岁（范围11 - 95岁）。416例患者中有6例（1.4%）发现有息肉。1例为炎性息肉，1例诊断为家族性腺瘤性息肉病，1例伴有盲肠癌。其余3例患者发现5个“散发性”腺瘤性息肉（患病率0.7%）。所有腺瘤性息肉均位于肝曲远端，仅表现为轻度异型性。平均大小为6.4毫米（范围2 - 20毫米）。与年龄调整后的西方人群相比，菲律宾人结直肠腺瘤的发病率较低。这一发现与结直肠癌的低发病率相吻合。腺瘤性息肉和结直肠癌低风险的记录表明，大规模筛查项目难以对菲律宾普通人群结直肠肿瘤的早期发现产生显著的积极影响。
