Steenkamp V, Gouws M C, Gulumian M, Elgorashi E E, van Staden J
Department of Urology, Faculty of Health Sciences, University of Pretoria, South Africa.
J Ethnopharmacol. 2006 Jan 3;103(1):71-5. doi: 10.1016/j.jep.2005.07.007. Epub 2005 Aug 24.
Crude water and ethanolic extracts of five herbal remedies reported in the literature for traditional treatment of benign prostatic hyperplasia (BPH) and/or prostatitis were investigated for their effect on hydroxyl scavenging activity, antibacterial activity and their ability to inhibit cyclooxygenase-1 and -2 (COX-1 and COX-2) catalysed prostaglandin biosynthesis. Both the water and ethanol extracts of Hypoxis hemerocallidea and Epilobium parviflorum inhibited the growth of Escherichia coli. All 10 extracts scavenged the hydroxyl radical but with various potencies (32-93%). Ethanolic extracts were the most active in inhibiting COX-1 catalysed prostaglandin biosynthesis. The ethanolic extract of Epilobium parviflorum showed inhibitory effects on both the COX-1 and -2 catalysed prostaglandin biosynthesis, inhibited growth of Escherichia coli and exerted antioxidant activity. Although these results support the traditional use of Epilobium parviflorum for treatment of prostatitis and BPH, further investigation is required, for this promising plant.
对文献中报道的五种用于传统治疗良性前列腺增生（BPH）和/或前列腺炎的草药的粗水提取物和乙醇提取物进行了研究，考察它们对羟基清除活性、抗菌活性以及抑制环氧合酶-1和-2（COX-1和COX-2）催化的前列腺素生物合成能力的影响。仙茅和小花柳叶菜的水提取物和乙醇提取物均能抑制大肠杆菌的生长。所有10种提取物均能清除羟基自由基，但清除能力各不相同（32%-93%）。乙醇提取物在抑制COX-1催化的前列腺素生物合成方面活性最强。小花柳叶菜的乙醇提取物对COX-1和COX-2催化的前列腺素生物合成均有抑制作用，能抑制大肠杆菌的生长并具有抗氧化活性。尽管这些结果支持小花柳叶菜用于治疗前列腺炎和BPH的传统用途，但对于这种有前景的植物仍需进一步研究。
