Galderisi U, Cipollaro M, Giordano A
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA, USA.
Cell Death Differ. 2006 Jan;13(1):5-11. doi: 10.1038/sj.cdd.4401757.
An increasing body of research is showing that cancers might contain their own stem cells. In fact, cancer cells, like stem cells, can proliferate indefinitely through a deregulated cellular self-renewal capacity. This raises the possibility that some features of tumor cells may be due to cancer stem cells. Stem cell-like cancer cells were isolated from several solid tumors. Now, evidence has shown that brain cancers, such as glioblastomas, medulloblastomas and astrocytomas, also contain cells that may be multipotent neural stem cell-like cells. In this review, we discuss the results of these studies, along with the molecular pathways that could be involved in cancer stem cell physiopathology.
越来越多的研究表明，癌症可能含有自身的干细胞。事实上，癌细胞与干细胞一样，能够通过失调的细胞自我更新能力无限增殖。这就增加了肿瘤细胞的某些特征可能归因于癌症干细胞的可能性。已从多种实体瘤中分离出干细胞样癌细胞。现在，有证据表明，脑癌，如胶质母细胞瘤、髓母细胞瘤和星形细胞瘤，也含有可能是多能神经干细胞样的细胞。在这篇综述中，我们讨论了这些研究的结果，以及可能参与癌症干细胞生理病理学的分子途径。
