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[侵袭性肺曲霉病作为长期抗生素治疗的并发症]

[Invasive pulmonary aspergillosis as a complication of prolonged antibiotic therapy].

作者信息

Kamiński Janusz, Zielińska-Leś Izabela, Kozielski Jerzy

机构信息

Klinika Chorób Płuc i Gruźlicy w Zabrzu Slaskiej Akademii Medycznej w Katowicach.

出版信息

Pol Merkur Lekarski. 2005 Jun;18(108):700-2.

Abstract

In this study we present the case of 53 year old woman hospitalized in the Department of Lung Diseases and Tuberculosis in Zabrze, Silesian Medical University in Katowice, due to chronic cough and infiltration in the chest radiogram. Prior to the admission, the patient received long-lasting antibiotic ambulatory treatment leveled at laryngobronchitis. After admission the patient underwent bronchofiberoscopy during which a sample for mycological examination of bronchoalveolar lavage was taken. The result of the examination made possible to give the diagnosis--invasive pulmonary aspergillosis. Proper antifungal treatment was used and in consequence considerable improvement in both clinical and radiological state was achieved. Invasive pulmonary aspergillosis is mostly diagnosed in immunocompromised patients. The patient described in this case had none risk factors. Based on that particular case we may state a hypothesis that a prolonged antibiotic therapy is an important risk factor of invasive pulmonary aspergillosis incidence.

摘要

在本研究中,我们报告了一名53岁女性的病例,该患者因慢性咳嗽和胸部X光片显示浸润影而入住卡托维兹西里西亚医科大学扎布热肺病与结核病科。入院前,患者接受了针对喉支气管炎的长期门诊抗生素治疗。入院后,患者接受了支气管纤维镜检查,在此期间采集了支气管肺泡灌洗样本进行真菌学检查。检查结果得以确诊——侵袭性肺曲霉病。采用了适当的抗真菌治疗,结果临床和影像学状态均有显著改善。侵袭性肺曲霉病大多在免疫功能低下的患者中被诊断出来。本病例中的患者没有任何风险因素。基于该特定病例,我们可以提出一个假设,即长期抗生素治疗是侵袭性肺曲霉病发病的一个重要风险因素。

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