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黑腹果蝇的超重与衰老。6. 自发运动活性

Hypergravity and aging in Drosophila melanogaster. 6. Spontaneous locomotor activity.

作者信息

Le Bourg E, Lints F A

机构信息

Université Paul-Sabatier, URA CNRS No. 664, Toulouse, France.

出版信息

Gerontology. 1992;38(1-2):71-9. doi: 10.1159/000213309.

DOI:10.1159/000213309
PMID:1612464
Abstract

The spontaneous locomotor activity (SLA) of Drosophila melanogaster flies kept at various gravity levels (1-5 g) was recorded in both longitudinal and cross-sectional experiments. No gravity level effect could be detected in the longitudinal one, probably because these flies were allowed (for technical reasons) to rest at 1 g for 15% of their life. By contrast, flies kept at 5 g in the cross-sectional experiment had lower SLA scores at middle and old age than both 1 and 3 g-kept flies. The results of this series of experiments on hypergravity (HG) effects on three forms of locomotor activity (climbing activity, patterns of movement and SLA) allow to conclude that aging is accelerated in HG, even if no longevity decrease could be detected in the 1-4 g range.

摘要

在纵向和横断面实验中记录了处于不同重力水平(1 - 5g)的黑腹果蝇的自发运动活性(SLA)。在纵向实验中未检测到重力水平效应,可能是因为(出于技术原因)这些果蝇在其生命的15%时间里被允许在1g重力下休息。相比之下,在横断面实验中,处于5g重力下的果蝇在中年和老年时的SLA得分低于处于1g和3g重力下的果蝇。这一系列关于超重力(HG)对三种运动活性形式(攀爬活性、运动模式和SLA)影响的实验结果表明,即使在1 - 4g范围内未检测到寿命缩短,但在HG环境中衰老会加速。

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