Bak Nikolaj Klausholt, Rohde Palle Duun, Kristensen Torsten Nygaard
Department of Chemistry and Bioscience, Aalborg University, Frederik Bajers Vej 7H, DK 9220 Aalborg, Denmark.
Department of Health Science and Technology, Aalborg University, Selma Lagerløfs Vej 249, DK 9260 Gistrup, Denmark.
Insects. 2023 Dec 26;15(1):9. doi: 10.3390/insects15010009.
Insufficient intake of essential nutrients, malnutrition is a major issue for millions of people and has a strong impact on the distribution and abundance of species in nature. In this study, we investigated the effect of malnutrition on several fitness components in the vinegar fly . Four diets with different nutritional values, including three diluted diets of an optimal nutritional balanced diet, were used as feed sources. The effect of malnutrition on fitness components linked to healthspan, the period of life spent in good health conditions, was evaluated by quantifying the flies' lifespan, locomotor activity, heat stress tolerance, lipid content, and dry weight. The results showed that malnutrition had severe negative impact, such as reduced lifespan, locomotor activity, heat stress tolerance, fat content, and dry weight. The negative phenotypic effects were highly sex-dependent, with males being more negatively impacted by malnutrition compared to females. These findings highlight important detrimental and sex-specific effects of malnutrition not only on lifespan but also on traits related to healthspan.
必需营养素摄入不足，营养不良是数百万人面临的一个主要问题，并且对自然界物种的分布和丰富度有强烈影响。在本研究中，我们调查了营养不良对果蝇几个健康指标的影响。使用四种具有不同营养价值的食物，包括三种最佳营养平衡饮食的稀释饮食，作为食物来源。通过量化果蝇的寿命、运动活性、热应激耐受性、脂质含量和干重，评估营养不良对与健康寿命（在良好健康状况下度过的生命时期）相关的健康指标的影响。结果表明，营养不良有严重的负面影响，如寿命缩短、运动活性降低、热应激耐受性下降、脂肪含量减少和干重降低。负面表型效应高度依赖性别，与雌性相比，雄性受营养不良的负面影响更大。这些发现突出了营养不良不仅对寿命而且对与健康寿命相关的性状具有重要的有害和性别特异性影响。
