Devoto Alessandra, Manganelli Sara, Lucidi Fabio, Lombardo Caterina, Russo Paolo Maria, Violani Cristiano
Department of Psychology, University of Rome, La Sapienza, Italy.
Sleep. 2005 Jul;28(7):859-63. doi: 10.1093/sleep/28.7.859.
The aim of this study is to evaluate whether the cortical arousal level in subjects with primary insomnia varies according to their quality of nighttime sleep.
The P300 ERP was recorded each day, before and after sleep actigraphically monitored for 1 week. For each participant, the nights of worst- and best-quality sleep were identified.
Seven subjects with primary insomnia and 7 control subjects.
The P300 amplitudes were compared by considering group (insomnia vs control), night (worst vs best), and moment of recording (before vs after sleep) as factors. The subjects with insomnia showed higher P300 amplitudes, as compared with amplitudes of control subjects, only for the worst night of sleep.
Results indicate a relationship between variations in sleep quality and cortical arousal level in subjects with primary insomnia.
本研究旨在评估原发性失眠患者的皮质唤醒水平是否会根据其夜间睡眠质量而有所不同。
在通过睡眠活动记录仪监测1周睡眠前后，每天记录P300事件相关电位。为每位参与者确定睡眠质量最差和最好的夜晚。
7名原发性失眠患者和7名对照受试者。
将P300波幅作为因变量，考虑组（失眠组与对照组）、夜晚（最差与最好）和记录时刻（睡眠前与睡眠后）作为因素进行比较。与对照受试者的波幅相比，失眠患者仅在睡眠最差的夜晚表现出较高的P300波幅。
结果表明原发性失眠患者的睡眠质量变化与皮质唤醒水平之间存在关联。
