Ferini-Strambi L, Franceschi M, Pinto P, Zucconi M, Smirne S
Department of Neurology, State University, Milan, Italy.
Gerontology. 1992;38(1-2):92-8. doi: 10.1159/000213312.
Twenty-six patients with untreated mild to moderate Parkinson's disease (PD) lasting 5 years or less, were investigated in the sleep laboratory. Sleep architecture and respiration during sleep did not significantly differ from age-matched controls. PD patients showed defective cardiac autonomic control during sleep, mainly parasympathetic but also sympathetic in nature, although they had normal results in conventional autonomic tests during wakefulness. Therefore, autonomic cardiac involvement seems to be an early sign of PD.
26例未经治疗、病程5年及以内的轻至中度帕金森病（PD）患者在睡眠实验室接受了调查。睡眠结构和睡眠期间的呼吸与年龄匹配的对照组相比无显著差异。PD患者在睡眠期间表现出心脏自主神经控制缺陷，主要是副交感神经性质，但也有交感神经性质，尽管他们在清醒时的传统自主神经测试结果正常。因此，自主神经心脏受累似乎是PD的早期迹象。
