Thomas A G, Miller V, Taylor F, Maycock P, Scrimgeour C M, Rennie M J
Booth Hall Children's Hospital, Blackley, Manchester.
Gut. 1992 May;33(5):675-7. doi: 10.1136/gut.33.5.675.
In order to investigate the effects of treatment on protein metabolism in childhood Crohn's disease whole body protein turnover was measured using a primed constant intravenous infusion of L-[1-13C]leucine and mass spectrometry in 10 children with active disease. Mean rates of protein synthesis and breakdown markedly decreased after treatment with steroids (four) or an elemental diet (six). This suggests that protein synthesis and breakdown are increased during active Crohn's disease in children and are reduced after induction of remission regardless of the type of treatment.
为了研究治疗对儿童克罗恩病蛋白质代谢的影响，对10名患有活动性疾病的儿童采用L-[1-¹³C]亮氨酸的首剂量恒定静脉输注和质谱分析法测量了全身蛋白质周转率。使用类固醇（4例）或要素饮食（6例）治疗后，蛋白质合成和分解的平均速率显著降低。这表明儿童活动性克罗恩病期间蛋白质合成和分解增加，且无论治疗类型如何，诱导缓解后均会降低。
