Papadopoulou A, Rawashdeh M O, Brown G A, McNeish A S, Booth I W
University of Birmingham, Institute of Child Health, UK.
Acta Paediatr. 1995 Jan;84(1):79-83. doi: 10.1111/j.1651-2227.1995.tb13490.x.
The short- and long-term effects of an elemental diet in children with acute Crohn's disease were compared with those of prednisolone in historical controls. Clinical remission was induced in 25 of 30 and in 18 of 28 episodes treated for six weeks with an elemental diet and prednisolone. Patients with proximal disease had longer remission after treatment with an elemental diet (p < 0.05) than did patients with colonic disease after treatment with prednisolone (p < 0.01). Disease activity index score improved in both groups compared with the pretreatment scores (p < 0.05). However, the improvement in the elemental diet group was significantly better than in the prednisolone group (p < 0.001). Changes in linear growth were better after treatment with an elemental diet compared with steroids (p < 0.001). Serum albumin and haematocrit concentrations all improved significantly in the children treated with an elemental diet (p < 0.001) but not in those treated with steroids. Thus an elemental diet was better than prednisolone in proximal disease and confirmed improved growth and nutritional status.
将患有急性克罗恩病的儿童采用要素饮食的短期和长期效果，与历史对照中使用泼尼松龙的效果进行了比较。在接受要素饮食和泼尼松龙治疗六周的30例发作中有25例、28例发作中有18例实现了临床缓解。近端疾病患者接受要素饮食治疗后的缓解期（p < 0.05）长于结肠疾病患者接受泼尼松龙治疗后的缓解期（p < 0.01）。与治疗前评分相比，两组的疾病活动指数评分均有所改善（p < 0.05）。然而，要素饮食组的改善明显优于泼尼松龙组（p < 0.001）。与使用类固醇相比，采用要素饮食治疗后线性生长的变化更好（p < 0.001）。接受要素饮食治疗的儿童血清白蛋白和血细胞比容浓度均显著改善（p < 0.001），但接受类固醇治疗的儿童则未改善。因此，在近端疾病中要素饮食优于泼尼松龙，并证实其能改善生长和营养状况。
