Nabkasorn Chanudda, Miyai Nobuyuki, Sootmongkol Anek, Junprasert Suwanna, Yamamoto Hiroichi, Arita Mikio, Miyashita Kazuhisa
Department of Hygiene, School of Medicine, Wakayama Medical University, Wakayama, Japan.
Eur J Public Health. 2006 Apr;16(2):179-84. doi: 10.1093/eurpub/cki159. Epub 2005 Aug 26.
Regular physical exercise may improve a variety of physiological and psychological factors in depressive persons. However, there is little experimental evidence to support this assumption for adolescent populations. We conducted a randomized controlled trial to investigate the effect of physical exercise on depressive state, the excretions of stress hormones and physiological fitness variables in adolescent females with depressive symptoms.
Forty-nine female volunteers (aged 18-20 years; mean 18.8 +/- 0.7 years) with mild-to-moderate depressive symptoms, as measured by the Centre for Epidemiologic Studies Depression (CES-D) scale, were randomly assigned to either an exercise regimen or usual daily activities for 8 weeks. The subjects were then crossed over to the alternate regimen for an additional 8-week period. The exercise program consisted of five 50-min sessions per week of a group jogging training at a mild intensity. The variables measured were CES-D rating scale, urinary cortisol and epinephrine levels, and cardiorespiratory factors at rest and during exercise endurance test.
After the sessions of exercise the CES-D total depressive score showed a significant decrease, whereas no effect was observed after the period of usual daily activities (ANOVA). Twenty-four hour excretions of cortisol and epinephrine in urine were reduced due to the exercise regimen. The training group had a significantly reduced resting heart rate and increased peak oxygen uptake and lung capacity.
The findings of this study suggest that a group jogging exercise may be effective in improving depressive state, hormonal response to stress and physiological fitness of adolescent females with depressive symptoms.
规律的体育锻炼可能会改善抑郁症患者的多种生理和心理因素。然而，几乎没有实验证据支持这一假设适用于青少年群体。我们进行了一项随机对照试验，以研究体育锻炼对有抑郁症状的青春期女性的抑郁状态、应激激素分泌和生理健康变量的影响。
49名年龄在18至20岁（平均18.8±0.7岁）、通过流行病学研究中心抑郁量表（CES-D）测量有轻度至中度抑郁症状的女性志愿者，被随机分配到锻炼方案组或日常活动组，为期8周。然后，受试者交叉到另一方案，再进行8周。锻炼计划包括每周进行五次50分钟的轻度强度集体慢跑训练。测量的变量包括CES-D评分量表、尿皮质醇和肾上腺素水平，以及静息状态和运动耐力测试期间的心肺因素。
锻炼期后CES-D总抑郁评分显著降低，而日常活动期后未观察到效果（方差分析）。锻炼方案使尿中皮质醇和肾上腺素的24小时排泄量减少。训练组静息心率显著降低，峰值摄氧量和肺活量增加。
本研究结果表明，集体慢跑锻炼可能对改善有抑郁症状的青春期女性的抑郁状态、应激激素反应和生理健康有效。
