与感染减毒毒力的SHIV 89.6的恒河猴抵御阴道SIV攻击相关的免疫机制。
Immune mechanisms associated with protection from vaginal SIV challenge in rhesus monkeys infected with virulence-attenuated SHIV 89.6.
作者信息
Miller Christopher J, Abel Kristina
机构信息
California National Primate Research Center.
出版信息
J Med Primatol. 2005 Oct;34(5-6):271-81. doi: 10.1111/j.1600-0684.2005.00125.x.
Abstract
Although live-attenuated human immunodeficiency virus-1 (HIV) vaccines may never be used clinically, these vaccines have provided the most durable protection from intravenous (IV) challenge in the simian immunodeficiency virus (SIV)/rhesus macaque model. Systemic infection with virulence attenuated-simian-human immunodeficiency virus (SHIV) 89.6 provides protection against vaginal SIV challenge. This paper reviews the findings related to the innate and adaptive immune responses and the role of inflammation associated with protection in the SHIV 89.6/SIVmac239 model. By an as yet undefined mechanism, most monkeys vaccinated with live-attenuated SHIV 89.6 mounted effective anti-viral CD8+ T cell responses while avoiding the self-destructive inflammatory cycle found in the lymphoid tissues of unprotected and unvaccinated monkeys.
摘要
尽管减毒活人类免疫缺陷病毒1型（HIV）疫苗可能永远不会用于临床，但这些疫苗在猿猴免疫缺陷病毒（SIV）/恒河猴模型中对静脉内（IV）攻击提供了最持久的保护。用毒力减弱的猿猴-人类免疫缺陷病毒（SHIV）89.6进行全身感染可提供针对阴道SIV攻击的保护。本文综述了与SHIV 89.6/SIVmac239模型中固有和适应性免疫反应以及与保护相关的炎症作用有关的研究结果。通过一种尚未明确的机制，大多数接种减毒活SHIV 89.6的猴子产生了有效的抗病毒CD8+T细胞反应，同时避免了在未受保护和未接种疫苗的猴子的淋巴组织中发现的自我毁灭性炎症循环。
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