Kitis Omer, Altay Hakan, Calli Cem, Yunten Nilgun, Akalin Taner, Yurtseven Taskin
Department of Radiology, School of Medicine, Ege University, 35100 Bornova, Izmir, Turkey.
Eur J Radiol. 2005 Sep;55(3):393-400. doi: 10.1016/j.ejrad.2005.02.004.
To determine whether diffusion-weighted imaging by using minimum apparent diffusion coefficient (ADC(min)) values could differentiate various brain tumors including gliomas, metastases, and lymphomas.
We examined 65 patients with histologically or clinically diagnosed brain tumors (12 low-grade gliomas, 31 high-grade gliomas, 14 metastatic tumors, and 8 lymphomas) using a 1.5 T MR unit. On diffusion-weighted imaging, the ADC(min) values were measured within the tumors and mean values were evaluated regarding statistical differences between groups.
The ADC(min) values of low-grade gliomas (1.09+/-0.20 x 10(-3)mm(2)/s) were significantly higher (p<.001) than those of other tumors. There were no statistical significant differences between glioblastomas (0.70+/-0.16 mm(2)/s), anaplastic astrocytomas (0.77+/-0.21 mm(2)/s), metastases (0.78+/-0.21 mm(2)/s), and lymphomas. But, lymphomas had lower mean ADC(min) values (0.54+/-0.10mm(2)/s) than high-grade gliomas and metastases.
The ADC measurements may help to differentiate low-grade gliomas from high-grade gliomas, metastases, and lymphomas. Although there is no statistical difference, lymphomas seem to have marked restriction in diffusion coefficients.
确定使用最小表观扩散系数（ADC(min)）值的扩散加权成像是否能够区分包括胶质瘤、转移瘤和淋巴瘤在内的各种脑肿瘤。
我们使用1.5T磁共振设备检查了65例经组织学或临床诊断为脑肿瘤的患者（12例低级别胶质瘤、31例高级别胶质瘤、14例转移瘤和8例淋巴瘤）。在扩散加权成像上，测量肿瘤内的ADC(min)值，并评估各组之间的平均值有无统计学差异。
低级别胶质瘤的ADC(min)值（1.09±0.20×10(-3)mm(2)/s）显著高于其他肿瘤（p<0.001）。胶质母细胞瘤（0.70±0.16mm(2)/s）、间变性星形细胞瘤（0.77±0.21mm(2)/s）、转移瘤（0.78±0.21mm(2)/s）和淋巴瘤之间无统计学显著差异。但是，淋巴瘤的平均ADC(min)值（0.54±0.10mm(2)/s）低于高级别胶质瘤和转移瘤。
ADC测量可能有助于区分低级别胶质瘤与高级别胶质瘤、转移瘤和淋巴瘤。尽管无统计学差异，但淋巴瘤在扩散系数方面似乎有明显受限。
