Momeni Farideh, Abedi-Firouzjah Razzagh, Farshidfar Zahra, Taleinezhad Nastaran, Ansari Leila, Razmkon Ali, Banaei Amin, Mehdizadeh Alireza
Medical Physics and Biomedical Engineering Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran.
Oman Med J. 2021 Mar 31;36(2):e251. doi: 10.5001/omj.2021.59. eCollection 2021 Mar.
Our study aimed to apply the apparent diffusion coefficient (ADC) values to quantify the differences between low- and high-grade glioma tumors.
We conducted a multicenter, retrospective study between September to December 2019. Magnetic resonance imaging (MRI) diffusion-weighted images (DWIs), and the pathologic findings of 56 patients with glioma tumors (low grade = 28 and high grade = 28) were assessed to measure the ADC values in the tumor center, tumor edema, boundary area between tumor with normal tissue, and inside the healthy hemisphere. These values were compared between the two groups, and cut-off values were calculated using the receiver operating characteristic curve.
We saw significant differences between the mean ADC values measured in the tumor center and edema between high- and low-grade tumors (< 0.005). The ADC values in the boundary area between tumors with normal tissue and inside healthy hemisphere did not significantly differ in the groups. The ADC values at tumor center and edema were higher than 1.12 × 10 mm/s (sensitivity = 100% and specificity = 96.0%) and 1.15 × 10 mm/s (sensitivity = 75.0% and specificity = 64.0%), respectively, could be classified as low-grade tumors.
The ADC values from the MRI DWIs in the tumor center and edema could be used as an appropriate method for investigating the differences between low- and high-grade glioma tumors. The ADC values in the boundary area and healthy tissues had no diagnostic values in grading the glioma tumors.
本研究旨在应用表观扩散系数（ADC）值来量化低级别和高级别胶质瘤肿瘤之间的差异。
我们在2019年9月至12月期间进行了一项多中心回顾性研究。对56例胶质瘤患者（低级别=28例，高级别=28例）的磁共振成像（MRI）扩散加权成像（DWI）及病理结果进行评估，以测量肿瘤中心、肿瘤水肿、肿瘤与正常组织边界区域以及健康脑半球内的ADC值。比较两组之间的这些值，并使用受试者工作特征曲线计算临界值。
我们发现高级别和低级别肿瘤在肿瘤中心和水肿区域测得的平均ADC值之间存在显著差异（<0.005）。肿瘤与正常组织边界区域以及健康脑半球内的ADC值在两组之间无显著差异。肿瘤中心和水肿区域的ADC值分别高于1.12×10⁻³mm²/s（灵敏度=100%，特异度=96.0%）和1.15×10⁻³mm²/s（灵敏度=75.0%，特异度=64.0%）时，可被分类为低级别肿瘤。
MRI DWI在肿瘤中心和水肿区域的ADC值可作为研究低级别和高级别胶质瘤肿瘤差异的合适方法。边界区域和健康组织中的ADC值在胶质瘤肿瘤分级中无诊断价值。
