Vrsalovic Maruska Marusic, Korac Petra, Dominis Mara, Ostojic Slobodanka, Mannhalter Christine, Kusec Rajko
Institute of Clinical Chemistry, Division of Molecular Diagnostics, Merkur University Hospital, Zagreb, Croatia.
Hematol Oncol. 2004 Dec;22(4):169-77. doi: 10.1002/hon.740.
Angioimmunoblastic T-cell lymphoma (T-AIL) is a peripheral T-cell lymphoma of unknown etiology. Previous clonality studies have shown a heterogeneous composition of this disease with varying restrictions of B- and T-cell populations in the tumour. For the first time in a single study and in the same pathological materials, we have analysed, lymphoid cell clonality and occurrence of human herpes viruses and Epstein Barr virus. Of 18 cases 12 (66.6%) had clonal T- and three (16.6%) had clonal B-cells. Presence of the lymphotropic viral genome of HHV6 was detected in four of 18 lymph node biopsies from T-AIL patients (22%), all were TCRgamma clonal. No HHV8 were found. Epstein Barr genome was found in 40% of cases. There was no significant association between T-cell clonality and HHV-6 or EBV infection, or between B-cell clonality and any virus infection. We conclude that T-AIL is a biologically and clinically heterogeneous entity whose true nature remains to be clarified.
血管免疫母细胞性T细胞淋巴瘤（T-AIL）是一种病因不明的外周T细胞淋巴瘤。以往的克隆性研究表明，该疾病的组成具有异质性，肿瘤中的B细胞和T细胞群体存在不同程度的受限。在一项单一研究中，我们首次对相同病理材料中的淋巴样细胞克隆性以及人类疱疹病毒和EB病毒的存在情况进行了分析。18例病例中，12例（66.6%）有克隆性T细胞，3例（16.6%）有克隆性B细胞。在18例T-AIL患者的淋巴结活检样本中，有4例（22%）检测到嗜淋巴细胞性HHV6病毒基因组，均为TCRγ克隆性。未发现HHV8。40%的病例中发现EB病毒基因组。T细胞克隆性与HHV-6或EB病毒感染之间，以及B细胞克隆性与任何病毒感染之间均无显著关联。我们得出结论，T-AIL是一种生物学和临床均具有异质性的实体，其真正性质仍有待阐明。
