超螺旋结构域的组织及其通过转录进行的重组。
Organization of supercoil domains and their reorganization by transcription.
作者信息
Deng Shuang, Stein Richard A, Higgins N Patrick
机构信息
Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL-35294, USA.
出版信息
Mol Microbiol. 2005 Sep;57(6):1511-21. doi: 10.1111/j.1365-2958.2005.04796.x.
Abstract
During a normal cell cycle, chromosomes are exposed to many biochemical reactions that require specific types of DNA movement. Separation forces move replicated chromosomes into separate sister cell compartments during cell division, and the contemporaneous acts of DNA replication, RNA transcription and cotranscriptional translation of membrane proteins cause specific regions of DNA to twist, writhe and expand or contract. Recent experiments indicate that a dynamic and stochastic mechanism creates supercoil DNA domains soon after DNA replication. Domain structure is subsequently reorganized by RNA transcription. Examples of transcription-dependent chromosome remodelling are also emerging from eukaryotic cell systems.
摘要
在正常细胞周期中，染色体要经历许多需要特定类型DNA移动的生化反应。在细胞分裂过程中，分离力将复制后的染色体移动到不同的子细胞区室中，同时，DNA复制、RNA转录以及膜蛋白的共转录翻译等过程会使DNA的特定区域发生扭曲、缠绕以及伸展或收缩。最近的实验表明，一种动态随机机制在DNA复制后不久就会产生超螺旋DNA结构域。随后，RNA转录会对结构域结构进行重新组织。真核细胞系统中也不断出现转录依赖性染色体重塑的例子。
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