Ijaz Samreen, Arnold Eve, Banks Malcolm, Bendall Richard P, Cramp Matthew E, Cunningham Richard, Dalton Harry R, Harrison Tim J, Hill Simon F, Macfarlane Lorna, Meigh Rolf E, Shafi Shuja, Sheppard Martin J, Smithson Jacquie, Wilson Melanie P, Teo Chong-Gee
Virus Reference Division, Centre for Infections, Health Protection Agency, University College London, London, United Kingdom.
J Infect Dis. 2005 Oct 1;192(7):1166-72. doi: 10.1086/444396. Epub 2005 Aug 22.
Between 1996 and 2003, 186 cases of hepatitis E were serologically diagnosed. Of these, 17 (9%) were not associated with recent travel abroad. Patients were >55 years old (range, 56-82 years old) and tended to be male (76%). Two patients presented with fulminant hepatitis. A total of 129 (69%) cases were associated with recent travel to countries where hepatitis E virus (HEV) is hyperendemic. Compared with patients with travel-associated disease, patients with non-travel-associated disease were more likely to be older, living in coastal or estuarine areas, not of South Asian ethnicity, and infected by genotype 3 strains of HEV. The genotype 3 subgenomic nucleotide sequences were unique and closely related to those from British pigs. Patients infected by HEV indigenous to England and Wales tended to belong to a distinct demographic group, there were multiple sources of infection, and pigs might have been a viral reservoir.
1996年至2003年间，血清学诊断出186例戊型肝炎病例。其中，17例（9%）与近期出国旅行无关。患者年龄大于55岁（范围为56至82岁），且男性居多（76%）。两名患者出现暴发性肝炎。共有129例（69%）病例与近期前往戊型肝炎病毒（HEV）高度流行国家的旅行有关。与旅行相关疾病患者相比，非旅行相关疾病患者更可能年龄较大、居住在沿海或河口地区、非南亚族裔，且感染的是HEV 3型毒株。3型亚基因组核苷酸序列独特，且与英国猪的序列密切相关。英格兰和威尔士本土感染HEV的患者往往属于一个独特的人群，存在多种感染源，猪可能是病毒储存宿主。
