Hill William A, Randolph Mildred M, Boyd Keli L, Mandrell Timothy D
Department of Comparative Medicine, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Contemp Top Lab Anim Sci. 2005 Sep;44(5):31-4.
The tropical rat mite, Ornithonyssus bacoti, was identified in a colony of mutagenized and transgenic mice at a large academic institution. O. bacoti is an obligate, blood-feeding ectoparasite with an extensive host range. Although the source of the infestation was likely feral rodents, none were found in the room housing infested mice. We hypothesize that construction on the floor above the vivarium and compromised ceiling integrity within the animal room provided for vermin entry and subsequent O. bacoti infestation. O. bacoti infestation was eliminated by environmental decontamination with synthetic pyrethroids and weekly application of 7.4% permethrin-impregnated cotton balls to mouse caging for five consecutive weeks. Visual examination of the macroenvironment, microenvironment, and colony for 38 days confirmed the efficacy of treatment. We noted no treatment-related toxicities or effects on colony production.
在一所大型学术机构的一群诱变和转基因小鼠中发现了热带鼠螨（柏氏禽刺螨）。柏氏禽刺螨是一种专性吸血外寄生虫，宿主范围广泛。尽管感染源可能是野生啮齿动物，但在饲养受感染小鼠的房间里并未发现。我们推测，动物饲养室上方楼层的建筑施工以及动物房内天花板完整性受损，为害虫进入并随后感染柏氏禽刺螨提供了条件。通过用拟除虫菊酯进行环境净化，并连续五周每周在小鼠笼中放置7.4%氯菊酯浸渍棉球，消除了柏氏禽刺螨感染。对宏观环境、微观环境和鼠群进行38天的目视检查证实了治疗效果。我们未发现与治疗相关的毒性或对鼠群繁殖的影响。
