Salamalekis Emanouel, Bakas Panagiotis, Vitoratos Nikolaos, Eleptheriadis Makarios, Creatsas Georgios
2nd Department of Obstetrics and Gynecology, Aretaieio Hospital, University of Athens, Vas. Sofias Avenue 76, Athens, Greece.
Eur J Obstet Gynecol Reprod Biol. 2006 May 1;126(1):16-9. doi: 10.1016/j.ejogrb.2005.07.007. Epub 2005 Sep 1.
OBJECTIVE(S): To investigate if testosterone levels are higher in patients with preeclampsia compared to normotensive pregnant patients.
The levels of serum total and free testosterone, dehydroepiandrosterone sulfate, androstenedione and sex hormone binding globulin were estimated in 28 patients during the third trimester of pregnancy with established preeclampsia and 25 normotensive women.
No statistically significant differences were noted between the two groups regarding the maternal age, gestational age, body mass index (BMI) haematocrit and neonatal sex. The mean+/-S.D. total testosterone and free testosterone levels were significantly higher (p < 0.01) in the group with preeclapsia compared to the control group. The values of DHEA-S, androstenedione and sex hormone binding globulin were lower in the group with preeclampsia but the difference did not reach statistical significance.
CONCLUSION(S): The levels of total and free testosterone appear to be higher in patients with preeclampsia compared to normotensive pregnant women during the third trimester of pregnancy. This difference could indicate an involvement of testosterone in the pathophysiology of preeclampsia and stimulates research in the potential role of anti-androgens in the management of preeclampsia.
研究子痫前期患者的睾酮水平是否高于血压正常的孕妇。
对28例已确诊为子痫前期的妊娠晚期患者和25例血压正常的女性，测定其血清总睾酮、游离睾酮、硫酸脱氢表雄酮、雄烯二酮和性激素结合球蛋白水平。
两组在产妇年龄、孕周、体重指数（BMI）、血细胞比容和新生儿性别方面无统计学显著差异。子痫前期组的平均±标准差总睾酮和游离睾酮水平显著高于对照组（p < 0.01）。子痫前期组的硫酸脱氢表雄酮、雄烯二酮和性激素结合球蛋白值较低，但差异未达到统计学显著性。
与妊娠晚期血压正常的孕妇相比，子痫前期患者的总睾酮和游离睾酮水平似乎更高。这种差异可能表明睾酮参与了子痫前期的病理生理过程，并激发了对抗雄激素在子痫前期治疗中潜在作用的研究。
