Morr H
Respiration. 1979;38(5):273-9. doi: 10.1159/000194092.
The experiments reported in this work have been performed to measure the effects of acetylcholine and the anticholinergic agent ipratropium bromide on the antigen-induced release of histamine from sensitized human lung in vitro. Primarily, ipratropium bromide did not have any effect, even at higher concentrations. Acetylcholine at a concentration of 1 x 10(-7)M increased the antigen-induced release of histamine by approximately 41%. When the lung tissue was treated with ipratropium bromide before acetylcholine, the competitive inhibition of the cholinergic receptor almost completely abolished this acetylcholine-induced increase of histamine release. Therefore, in our opinion, anticholinergic agents are primarily useful in vagus-controlled chronic obstructive ventilatory disorders; they are of secondary importance in allergic bronchial asthma.
本研究中所报道的实验旨在测量乙酰胆碱和抗胆碱能药物异丙托溴铵对体外致敏人肺组织中抗原诱导的组胺释放的影响。首先，即使在较高浓度下，异丙托溴铵也没有任何作用。浓度为1×10⁻⁷M的乙酰胆碱使抗原诱导的组胺释放增加了约41%。当在给予乙酰胆碱之前先用异丙托溴铵处理肺组织时，胆碱能受体的竞争性抑制几乎完全消除了这种乙酰胆碱诱导的组胺释放增加。因此，我们认为，抗胆碱能药物主要用于迷走神经控制的慢性阻塞性通气障碍；它们在过敏性支气管哮喘中是次要的。
