Bugalho de Almeida A A, Zimmermann I, Ulmer W T
Klin Wochenschr. 1982 Jul 1;60(13):673-80. doi: 10.1007/BF01716800.
Patients with chronic obstructive bronchitis (non atopics) show significant increased histamine concentrations in the plasma. In these patients the histamine concentration in the whole blood was also higher. The histamine concentration in the blood reflect primarily the concentration of basophiles. In individual patients very high plasma and whole blood histamine concentrations were found. The concentration of histamine in the venous plasma was about 2/3 of this of the arterial plasma. No difference in basophile histamine concentration was observed between patients and controls. The histamine concentrations in the plasma reflect primarily the high local histamine concentration in the bronchial mucosa. The plasma histamine concentration itself does not act as direct bronchoconstrictor. The histamine dependent bronchoconstriction is believed to be mostly reflex bronchoconstriction by challenge locally the sensoric receptors in the bronchial mucosa.
慢性阻塞性支气管炎患者（非特应性）血浆中的组胺浓度显著升高。在这些患者中，全血中的组胺浓度也较高。血液中的组胺浓度主要反映嗜碱性粒细胞的浓度。在个别患者中，发现血浆和全血中的组胺浓度非常高。静脉血浆中的组胺浓度约为动脉血浆的2/3。患者与对照组之间的嗜碱性粒细胞组胺浓度未观察到差异。血浆中的组胺浓度主要反映支气管黏膜中局部组胺的高浓度。血浆组胺浓度本身并不直接起支气管收缩作用。组胺依赖性支气管收缩被认为主要是通过局部刺激支气管黏膜中的感觉受体而引起的反射性支气管收缩。
