Leclerc S, Clerici T, Rybojad M, Girszyn N, Morel P, Janin A, Vignon-Pennamen M-D
Service d'Anatomie Pathologique, Hôpital Saint-Louis, Paris.
Ann Dermatol Venereol. 2005 Jun-Jul;132(6-7 Pt 1):546-9. doi: 10.1016/s0151-9638(05)79336-4.
Multinucleate cell angiohistiocytoma is a rare entity. We report two unusual cases of this lesion.
A 39 year-old man had presented since two years an arciform papular eruption of the forehead. A 40 year-old woman had a disseminated maculo-papular eruption since three years. Histological examination of skin samples of the two patients showed a dermal small vessel proliferation, associated with multinucleate cells, and confirmed the diagnosis of multinucleate cell angiohistiocytoma.
Our cases, typical histologically, have unusual clinical presentation (first case observed in a man, and the second in a disseminated form). Multinucleate cell angiohistiocytoma is a rare benign vascular proliferation individualized in 1985. Clinically, the lesion consists in small circumscribed papules. Acral sites and notably of the dorsum of the hands are the more frequent topography. It generally occurs in women aged over 50 years. Histologically, there is a dermal proliferation of capillaries and venules, and a fibrosis associated with the interstitial mononucleate cells and multinucleate cells.
多核细胞血管组织细胞瘤是一种罕见的疾病。我们报告两例该病变的不寻常病例。
一名39岁男性两年来前额出现弧形丘疹性皮疹。一名40岁女性三年来出现播散性斑丘疹。对两名患者的皮肤样本进行组织学检查显示真皮小血管增生，并伴有多核细胞，确诊为多核细胞血管组织细胞瘤。
我们的病例在组织学上具有典型性，但临床表现不寻常（第一例见于男性，第二例为播散性）。多核细胞血管组织细胞瘤是1985年确定的一种罕见的良性血管增生。临床上，病变表现为小的边界清楚的丘疹。手部背部等肢端部位是较常见的发病部位。它通常发生在50岁以上的女性。组织学上，有真皮毛细血管和小静脉增生，以及与间质单核细胞和多核细胞相关的纤维化。
