Division of Dermatology and Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, NS.
J Cutan Med Surg. 2010 Jul-Aug;14(4):178-80. doi: 10.2310/7750.2010.09046.
multinucleate cell angiohistiocytoma is a rare benign fibrohistiocytic and vascular proliferation, typically characterized by the development of solitary papules, in an acral distribution in otherwise healthy late middle-aged to elderly women.
our objectives are to present a novel case of generalized multinucleate cell angiohistiocytoma and to review the current literature regarding the clinical and histologic findings in this condition, as well as its potential causes and treatments.
we describe a 35-year-old man who presented with generalized asymptomatic firm violaceous papules. Histopathology revealed dermal vascular proliferation; a perivascular infiltrate of lymphocytes, histiocytes, neutrophils, and plasma cells; thickened surrounding collagen bundles; and characteristic multinucleate cells with scalloped borders.
our patient is one of three patients reported to date with generalized lesions of multinucleate cell angiohistiocytoma who were all in a younger age group (20-40 years old) than previously reported for solitary lesions.
多核细胞血管组织细胞瘤是一种罕见的良性纤维组织细胞和血管增生，通常表现为孤立性丘疹，发生于四肢，分布于健康的中老年女性。
我们的目的是报告一例全身性多核细胞血管组织细胞瘤，并复习目前关于该疾病的临床和组织学表现，以及其潜在的病因和治疗方法。
我们描述了一名 35 岁男性，表现为全身性无症状的坚实紫红色丘疹。组织病理学显示真皮血管增生；血管周围淋巴细胞、组织细胞、中性粒细胞和浆细胞浸润；周围胶原束增厚；以及具有扇贝状边界的特征性多核细胞。
我们的患者是迄今为止报告的三例全身性多核细胞血管组织细胞瘤患者之一，他们均处于比以前报道的孤立性病变更年轻的年龄组（20-40 岁）。
