Annessi G, Girolomoni G, Giannetti A
Department of Dermatology, University of Modena, Italy.
Am J Dermatopathol. 1992 Aug;14(4):340-4. doi: 10.1097/00000372-199208000-00009.
We report a case of multinucleate cell angiohistiocytoma occurring in a 50-year-old woman and presenting with a 4-year history of asymptomatic red papules on the face. Histologically, there was a dermal vascular proliferation associated with numerous multinucleate cells. Immunohistochemical studies showed vascular spaces surrounded with mature vascular endothelial cells, and the presence of numerous interstitial factor XIIIa+ cells. Multinucleate cells exhibited intermediate filaments of the vimentin type, but were not stained by endothelial cell or macrophage markers, and were factor XIIIa-. This condition must be addressed in the differential diagnosis of other skin vascular proliferations, such as Kaposi's sarcoma and angiofibromas.
我们报告一例发生于一名50岁女性的多核细胞血管组织细胞瘤，该患者面部出现无症状红色丘疹已有4年病史。组织学检查显示真皮血管增生并伴有大量多核细胞。免疫组织化学研究表明血管腔隙被成熟的血管内皮细胞包绕，且存在大量间质因子XIIIa阳性细胞。多核细胞表现为波形蛋白类型的中间丝，但未被内皮细胞或巨噬细胞标志物染色，且因子XIIIa阴性。在鉴别诊断其他皮肤血管增生性疾病，如卡波西肉瘤和血管纤维瘤时，必须考虑到这种情况。
