Wagner H, Häberle H, Maier V, Lang R E
J Endocrinol Invest. 1978 Jul;1(3):215-20. doi: 10.1007/BF03350383.
The study was designed to investigate the effect of various neurotransmitters on the hypothalamus and pituitary gland to determine the sites of their action. Superfused isolated rat hypothalami and pituitary glands demonstrated basal secretion of arginine vasopressin (AVP) and repeated response to stimulation thus showing the viability of the preparation. Acetylcholine and histamine stimulated the release of AVP at the hypothalamic and pituitary levels; dopamine and norepinephrine released AVP in a dose related manner only from the hypothalamus; angiotensin II released AVP in the same fashion only from the pituitary gland. AVP secretion stimulated by dopamine and norepinephrine may represent synaptic inputs which are localized at the hypothalamus and must be distinguished from the site of action at the pituitary gland of angiotensin II.
本研究旨在调查各种神经递质对下丘脑和垂体的作用，以确定其作用位点。对分离的大鼠下丘脑和垂体进行灌流，结果显示精氨酸加压素（AVP）的基础分泌以及对刺激的重复反应，从而表明该制备物具有活性。乙酰胆碱和组胺在下丘脑和垂体水平刺激AVP的释放；多巴胺和去甲肾上腺素仅在下丘脑以剂量相关的方式释放AVP；血管紧张素II仅在垂体以相同方式释放AVP。多巴胺和去甲肾上腺素刺激的AVP分泌可能代表位于下丘脑的突触输入，必须与血管紧张素II在垂体的作用位点区分开来。
