Salimzadeh Hamideh, Bishehsari Faraz, Delavari Alireza, Barzin Gilda, Amani Mohammad, Majidi Azam, Sadjadi Alireza, Malekzadeh Reza
Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Shariati Hospital, Tehran, Iran.
Division of Gastroenterology, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA.
BMJ Open. 2016 Dec 20;6(12):e013833. doi: 10.1136/bmjopen-2016-013833.
We aimed to measure cancer knowledge and feasibility of a screening colonoscopy among a cohort of individuals at higher risk of colon cancer.
This study was conducted as part of an ongoing screening cohort, in which first degree relatives (FDRs) of patients with colon cancer are invited to participate in a free of charge screening colonoscopy. We enrolled 1017 FDRs in the study between 2013 and 2014 measuring their data on demographics, cancer knowledge and colonoscopy uptake. A p value of <0.05 was considered statistically significant.
The relative's mean age was 48.7 years. Only about 28% of FDRs were aware of their increased risk for cancer, near 35.0% had ever heard about colonoscopy with 22% aware of the correct age to start screening. Comparing cancer knowledge of FDRs at high risk versus those at moderate risk, we recorded non-significant differences (p>0.05). Almost two-thirds of FDRs expressed willingness to undergo a colonoscopy and 49.2% completed the procedure, of which 12.8% had advanced neoplasm.
Our data indicated that remarkable numbers of FDRs were not still informed of their cancer risk or never received a physician recommendation for screening. The desirable uptake at first invitation, which would be higher over successive invitations, supports the feasibility of a family-based recruitment approach for early screening. This has promising implications to introduce targeted screening colonoscopy into the healthcare system in Iran and other developing nations.
我们旨在测量一组患结肠癌风险较高的个体的癌症知识以及筛查结肠镜检查的可行性。
本研究是一项正在进行的筛查队列研究的一部分，在该研究中，邀请结肠癌患者的一级亲属（FDRs）免费参加筛查结肠镜检查。我们在2013年至2014年期间招募了1017名FDRs，测量他们的人口统计学数据、癌症知识和结肠镜检查接受情况。p值<0.05被认为具有统计学意义。
亲属的平均年龄为48.7岁。只有约28%的FDRs意识到自己患癌症的风险增加，近35.0%的人听说过结肠镜检查，其中22%的人知道开始筛查的正确年龄。比较高危FDRs和中危FDRs的癌症知识，我们记录到无显著差异（p>0.05）。近三分之二的FDRs表示愿意接受结肠镜检查，49.2%的人完成了该检查，其中12.8%患有进展期肿瘤。
我们的数据表明，相当数量的FDRs仍然不了解自己的癌症风险，或者从未收到医生的筛查建议。首次邀请时的理想接受率，在后续邀请中会更高，这支持了基于家庭的早期筛查招募方法的可行性。这对于在伊朗和其他发展中国家将有针对性的筛查结肠镜检查引入医疗保健系统具有广阔的前景。
