Maxwell M J, Muthu P, Pritty P E
Accident and Emergency Department, Derbyshire Royal Infirmary, Derby, UK.
Emerg Med J. 2002 May;19(3):265-7. doi: 10.1136/emj.19.3.265.
Colchicine overdose is uncommon but potentially life threatening. It is a safe drug when used according to established therapeutic guidelines but causes serious systemic effects if ingested in doses that exceed the recommendations. Overdose must therefore be recognised early and treated appropriately to optimise the outcome. A fatal case of colchicine overdose caused by inappropriate self medication is reported and to the best of the authors' knowledge, there has been no report of fatal accidental overdose in the United Kingdom. The pharmacology of colchicine, the clinical features associated with overdose, and the options for treatment are discussed.
秋水仙碱过量并不常见，但可能危及生命。按照既定的治疗指南使用时，它是一种安全的药物，但如果摄入剂量超过推荐量，会导致严重的全身影响。因此，必须尽早识别过量情况并进行适当治疗，以优化治疗结果。本文报告了一例因不当自我用药导致的秋水仙碱过量致死病例，据作者所知，英国尚无致命意外过量的报告。文中讨论了秋水仙碱的药理学、与过量相关的临床特征以及治疗选择。
