使用氧化铟纳米线和碳纳米管对前列腺特异性抗原进行互补检测。
Complementary detection of prostate-specific antigen using In2O3 nanowires and carbon nanotubes.
作者信息
Li Chao, Curreli Marco, Lin Henry, Lei Bo, Ishikawa F N, Datar Ram, Cote Richard J, Thompson Mark E, Zhou Chongwu
机构信息
Department of Electrical Engineering, University of Southern California, Los Angeles, California 90089, USA.
出版信息
J Am Chem Soc. 2005 Sep 14;127(36):12484-5. doi: 10.1021/ja053761g.
We report complementary detection of prostate-specific antigen (PSA) using n-type In2O3 nanowires and p-type carbon nanotubes. Our innovation involves developing an approach to covalently attach antibodies to In2O3 NW surfaces via the onsite surface synthesis of phosphonic acid-succinylimide ester. Electronic measurements under dry conditions revealed complementary response for In2O3 NW and SWNT devices after the binding of PSA. Real-time detection in solution has also been demonstrated for PSA down to 5 ng/mL, a benchmark concentration significant for clinical diagnosis of prostate cancer, which is the most frequently diagnosed cancer.
我们报告了使用n型氧化铟（In2O3）纳米线和p型碳纳米管对前列腺特异性抗原（PSA）进行互补检测。我们的创新之处在于开发了一种通过现场表面合成膦酸琥珀酰亚胺酯将抗体共价连接到In2O3纳米线表面的方法。在干燥条件下的电子测量显示，PSA结合后In2O3纳米线和单壁碳纳米管（SWNT）器件有互补响应。对于低至5 ng/mL的PSA，也已证明在溶液中可进行实时检测，这一基准浓度对前列腺癌的临床诊断具有重要意义，前列腺癌是最常被诊断出的癌症。
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