溶组织内阿米巴的编码和非编码基因组区域具有显著不同的序列多态性速率：对流行病学研究的启示。
Coding and noncoding genomic regions of Entamoeba histolytica have significantly different rates of sequence polymorphisms: implications for epidemiological studies.
作者信息
Bhattacharya Dhruva, Haque Rashidul, Singh Upinder
机构信息
Department of Microbiology and Immunology, Division of Infectious Diseases, Stanford, CA 94305, USA.
出版信息
J Clin Microbiol. 2005 Sep;43(9):4815-9. doi: 10.1128/JCM.43.9.4815-4819.2005.
Abstract
To evaluate genetic variability among Entamoeba histolytica strains, we sequenced 9,077 bp from each of 14 isolates. The polymorphism rates from coding and noncoding regions were significantly different (0.07% and 0.37%, respectively), indicating that these regions are subject to different selection pressures. Additionally, single nucleotide polymorphisms (SNPs) potentially associated with specific clinical outcomes were identified.
摘要
为评估溶组织内阿米巴菌株之间的遗传变异性，我们对14个分离株的每个菌株的9077个碱基对进行了测序。编码区和非编码区的多态性率存在显著差异（分别为0.07%和0.37%），这表明这些区域受到不同的选择压力。此外，还鉴定出了可能与特定临床结果相关的单核苷酸多态性（SNP）。
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