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临床环境中诊断溶组织内阿米巴的分子方法:综述

Molecular methods for diagnosis of Entamoeba histolytica in a clinical setting: an overview.

作者信息

Paul Jaishree, Srivastava Shweta, Bhattacharya Sudha

机构信息

Jawaharlal Nehru University, School of Life Sciences, Delhi 110067, India.

出版信息

Exp Parasitol. 2007 May;116(1):35-43. doi: 10.1016/j.exppara.2006.11.005. Epub 2006 Dec 26.

Abstract

The range of clinical outcomes following Entamoeba histolytica infection is likely to be influenced by the different strains of the parasite already existing in our population. There is a need for developing faster, reliable and reproducible methods for identifying the different strains of E. histolytica. This would have a major impact on the subsequent course of treatment given to patients. In the post-genomic era, different loci of the Entamoeba genome have been targeted for developing suitable probes and genetic markers. This review highlights the development made in this direction and the possibility of using these methods for routine testing of this parasite in clinical samples.

摘要

溶组织内阿米巴感染后的临床结果范围可能受到人群中已存在的不同寄生虫菌株的影响。需要开发更快、可靠且可重复的方法来鉴定溶组织内阿米巴的不同菌株。这将对给予患者的后续治疗过程产生重大影响。在后基因组时代,已针对溶组织内阿米巴基因组的不同位点开发合适的探针和遗传标记。本综述重点介绍了在这一方向上取得的进展以及将这些方法用于临床样本中该寄生虫常规检测的可能性。

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