Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Hannover, Germany.
Epilepsy Curr. 2005 May-Jun;5(3):107-12. doi: 10.1111/j.1535-7511.2005.05311.x.
Despite advancements in antiepileptic therapy, about one third of people with epilepsy will remain intractable to medication. The initial response to antiepileptic drug therapy is highly predictive of long-term outcome. However, the mechanisms of medical intractability of epilepsy are only incompletely understood. Current interest is focused on two hypotheses: overexpression of drug efflux transporters and alterations in drug targets in the brain, with the most relevant causative mechanism(s) still to be elucidated.
尽管抗癫痫治疗取得了进展,但仍有约三分之一的癫痫患者对药物治疗无反应。抗癫痫药物治疗的初始反应高度预测长期预后。然而,癫痫药物难治性的机制尚未完全阐明。目前的研究重点集中在两个假说上:药物外排转运体的过度表达和大脑中药物靶点的改变,最相关的致病机制仍有待阐明。