Duda Mariusz, Pajak Jacek
Silesia-Med, Specialist Oral Medicine Clinic, Katowice.
Ann Univ Mariae Curie Sklodowska Med. 2004;59(1):269-77.
Bone grafts and bone substitute biomaterial implemented in guided tissue regeneration should undergo the process of biological decomposition in the recipient's system. The aim of this work is the presentation of current views concerning the issue of Bio-Oss bovine bone bioresorption and their juxtaposition with the results of the author's own research. The work presents histopathological and immunohistochemical tests of the xenogeneic Bio-Oss preparation from biopsies carried out 30 months after implantation. It was observed that the preparations contained correct bone neighbouring remnant particles of Bio-Oss, intratrabecular fibromatosis around the implant, abundant vascularisation, absence of osteoid and of active inflammatory process. A small number of T and B lymphocytes was detected. The results obtained in the above-described case testify to the descending character of the inflammatory infiltration 30 months after the implementation of Bio-Oss and efficient restoration of the bone. The prevalent view in literature is that Bio-Oss is resorbable biomaterial. However, there are also reports questioning this view as remnants of Bio-Oss have been detected even 44 months after implantation into the bone defect. In the author's own cases, Bio-Oss remnants could be observed 30 months after implanting. It seems that although the creation of new bone structure is indisputable, the process of biological decomposition of Bio-Oss should be described as slow bioresorption.
应用于引导组织再生的骨移植材料和骨替代生物材料应在受体系统中经历生物分解过程。本研究的目的是介绍关于Bio-Oss牛骨生物吸收问题的当前观点，并将其与作者自己的研究结果并列呈现。该研究展示了植入30个月后从活检中获取的异种Bio-Oss制剂的组织病理学和免疫组织化学测试结果。观察到制剂中含有正常骨组织，周围有Bio-Oss的残余颗粒，植入物周围存在小梁内纤维瘤病，血管丰富，无类骨质且无活跃炎症过程。检测到少量T淋巴细胞和B淋巴细胞。上述病例中获得的结果证明了Bio-Oss植入30个月后炎症浸润呈下降趋势，且骨组织得到有效修复。文献中的普遍观点是Bio-Oss是可吸收生物材料。然而，也有报告对这一观点提出质疑，因为即使在植入骨缺损44个月后仍检测到Bio-Oss的残余物。在作者自己的病例中，植入30个月后仍可观察到Bio-Oss残余物。似乎尽管新骨结构的形成是无可争议的，但Bio-Oss的生物分解过程应被描述为缓慢的生物吸收。
