Nosál'ova G, Strapková A, Kardosová A, Capek P, Zathurecký L, Bukovská E
Lehrstuhl für Pathophysiologie und Pharmakologie, Medizinische Fakultät Comenius Universität, Bratislava, CSFR.
Pharmazie. 1992 Mar;47(3):224-6.
The complex extract and the polysaccharide isolated from the roots of marsh mallow were tested for antitussive activity in unanaesthetized cats of both sexes. Cough was elicited by mechanical stimulation of laryngopharyngeal and tracheobronchial mucous area of the respiratory system with a Nylon fibre (diameter 0.35 mm). Cough was evaluated on the basis of the changes in lateral tracheal pressure. The polysaccharide and the complex extract were administered p.o. in a dose of 50 and 100 mg/kg b.w., respectively. The efficiency of the mentioned compounds was compared with the cough-suppressing effect of drugs belonging to the non-narcotic antitussics. The results of the experiments showed that administration of the polysaccharide led to a statistically significant decrease of the number of cough efforts both from laryngopharyngeal and tracheobronchial areas of the the respiratory system. The polysaccharide in a dose of 50 mg/kg b.w. was as effective in inhibition of the cough reflex as Sirupus Althaeae in a dose of 1000 mg/kg b.w. and more effective than prenoxdiazine in a dose of 30 mg/kg b.w. However, the cough-suppressing effect of the polysaccharide was lower than that of dropropizine. The extract was less effective than the polysaccharide.
对从药蜀葵根部提取的复合提取物和多糖进行了两性未麻醉猫的镇咳活性测试。用尼龙纤维（直径0.35毫米）机械刺激呼吸系统的喉咽和气管支气管粘膜区域引发咳嗽。根据气管侧压的变化评估咳嗽。多糖和复合提取物分别以50和100毫克/千克体重的剂量口服给药。将上述化合物的效果与属于非麻醉性镇咳药的药物的镇咳效果进行比较。实验结果表明，给予多糖导致呼吸系统喉咽和气管支气管区域的咳嗽次数在统计学上显著减少。50毫克/千克体重剂量的多糖在抑制咳嗽反射方面与1000毫克/千克体重剂量的药蜀葵糖浆一样有效，且比30毫克/千克体重剂量的丙戊茶碱更有效。然而，多糖的镇咳效果低于二氧丙嗪。提取物的效果低于多糖。
