Odelius Karin, Plikk Peter, Albertsson Ann-Christine
Department of Fibre and Polymer Technology, Royal Institute of Technology, SE-100 44, Stockholm, Sweden.
Biomacromolecules. 2005 Sep-Oct;6(5):2718-25. doi: 10.1021/bm050190b.
Porous scaffolds of 1,5-dioxepan-2-one (DXO), L-lactide (LLA), and epsilon-caprolactone (CL) were prepared by a solvent casting, salt particulate leaching technique in which the composites were detached from their mold using a novel methanol swelling procedure. By incorporating DXO segments into polymers containing LLA or CL, an increase in hydrophilicity is achieved, and incorporating soft amorphous domains in the crystalline sections enables tailoring of the mechanical properties. The porosities of the scaffolds ranged from 89.2% to 94.6%, and the pores were shown to be interconnected. The materials were synthesized by bulk copolymerization of 1,5-dioxepan-2-one (DXO), L-lactide (LLA), and epsilon-caprolactone (CL) using stannous 2-ethylhexanoate as catalyst. The copolymers formed varied in structure; poly(DXO-co-CL) is random in its arrangement, whereas poly(DXO-co-LLA) and poly(LLA-co-CL) are more blocky in their structures.
采用溶剂浇铸-盐颗粒沥滤技术制备了由1,5 -二氧杂环庚烷-2-酮（DXO）、L-丙交酯（LLA）和ε-己内酯（CL）组成的多孔支架，其中复合材料通过一种新型甲醇溶胀程序从模具中分离出来。通过将DXO链段引入含LLA或CL的聚合物中，可提高亲水性，并且在结晶部分引入软无定形区域能够对机械性能进行定制。支架的孔隙率在89.2%至94.6%之间，且孔隙相互连通。这些材料是使用2-乙基己酸亚锡作为催化剂，通过1,5 -二氧杂环庚烷-2-酮（DXO）、L-丙交酯（LLA）和ε-己内酯（CL）的本体共聚合成的。形成的共聚物结构各异；聚（DXO-co-CL）排列无规，而聚（DXO-co-LLA）和聚（LLA-co-CL）结构更呈嵌段状。
