AB5亚基细菌毒素的筏式运输

Raft trafficking of AB5 subunit bacterial toxins.

作者信息

Lencer Wayne I, Saslowsky David

机构信息

GI Cell Biology, Enders 720, Children's Hospital Boston, the Harvard Digestive Diseases Center, and the Department of Pediatrics, Harvard Medical School, 300 Longwood Ave., Boston, MA 02115, USA.

出版信息

Biochim Biophys Acta. 2005 Dec 30;1746(3):314-21. doi: 10.1016/j.bbamcr.2005.07.007. Epub 2005 Aug 15.

DOI:10.1016/j.bbamcr.2005.07.007

PMID:16153723

Abstract

Cholera and the related AB(5)-subunit toxins co-opt plasma membrane (PM) glycolipids to move retrograde into the endoplasmic reticulum (ER) of the host cell where a portion of the toxin is retro-translocated to the cytosol to induce disease. Only glycolipids that associate strongly with detergent insoluble membrane microdomains can sort the toxins backwards from PM to ER. The way certain lipids and proteins are clustered in the plane of the membrane to form lipid rafts likely explains how the glycolipids can function as sorting motifs for the toxins.

摘要

霍乱毒素及相关的AB(5)亚基毒素利用质膜（PM）糖脂逆行进入宿主细胞的内质网（ER），在那里一部分毒素被逆向转运至胞质溶胶以引发疾病。只有与去污剂不溶性膜微区强烈结合的糖脂才能将毒素从质膜逆向分选至内质网。特定脂质和蛋白质在膜平面上聚集形成脂筏的方式，可能解释了糖脂如何作为毒素的分选基序发挥作用。