a Center for Translational Cognitive Neuroscience , VA Boston Healthcare System , Boston , MA , USA.
b Department of Psychology , Texas State University , San Marcos , TX , USA.
J Clin Exp Neuropsychol. 2019 Mar;41(2):204-218. doi: 10.1080/13803395.2018.1513453. Epub 2018 Sep 4.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that presents predominantly with impairments in learning and memory. Patients with AD are also susceptible to , a clinically relevant memory distortion where a patient remembers an incorrect memory that they believe to be true. The use of cognitive strategies to improve memory performance among patients with AD by reducing false memories has taken on added importance given the lack of disease-modifying agents for AD. However, existing evidence suggests that cognitive strategies to reduce false memories in patients with AD are of limited effectiveness, although these strategies may be useful at earlier stages of the disease. The purpose of this review is to examine experimental findings of false memories and associated memory processes in patients with mild cognitive impairment due to AD and mild AD dementia. Cognitive strategies to reduce false memories in these patient populations are also reviewed. Approaches to clinically relevant future research are suggested and discussed.
阿尔茨海默病（AD）是一种进行性神经退行性疾病，主要表现为学习和记忆障碍。AD 患者也容易出现，这是一种临床相关的记忆扭曲，患者会记住一个错误的记忆，他们认为是真实的。鉴于缺乏 AD 的疾病修饰药物，使用认知策略通过减少错误记忆来提高 AD 患者的记忆表现变得尤为重要。然而，现有证据表明，减少 AD 患者错误记忆的认知策略效果有限，尽管这些策略在疾病的早期阶段可能有用。本综述的目的是检查 AD 轻度认知障碍和轻度 AD 痴呆患者错误记忆和相关记忆过程的实验结果。还回顾了减少这些患者群体中错误记忆的认知策略。提出并讨论了与临床相关的未来研究方法。
