Uchida Ryuji, Imasato Rie, Yamaguchi Yuichi, Masuma Rokuro, Shiomi Kazuro, Tomoda Hiroshi, Omura Satoshi
The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 1088641, Japan.
J Antibiot (Tokyo). 2005 Jun;58(6):397-404. doi: 10.1038/ja.2005.50.
Four new antibiotics, sesquicillins B to E were isolated from the culture broth of Albophoma sp. FKI-1778 together with known sesquicillin (sesquicillin A in this paper). The structures of sesquicillins were elucidated by spectroscopic studies including various NMR experiments. All sesquicillins have a common pyrano-diterpene skeleton. Sesquicillins showed moderate inhibitory activity against the growth of Artemia salina (brine shrimps) and Jurkat cells.
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