He K, Zeng L, Shi G, Zhao G X, Kozlowski J F, McLaughlin J L
Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, USA.
J Nat Prod. 1997 Jan;60(1):38-40. doi: 10.1021/np960513c.
Two new sesquiterpenes, 10 alpha-hydroxyamorphan-4-en-3-one (1) and 4 alpha-methylcadinane-4 alpha-methyl-1 alpha,2 alpha,10 alpha-triol (2), together with four known compounds, sesquiterpenes 10 alpha-hydroxycadinan-4-en-3-one (3) and alpha-cadinol (4), diterpene ferruginol and lignan helioxanthin, were isolated from the whole plant of Taiwania cryptomerioides under bioassay-guided fractionations. The structures of 1 and 2 were elucidated mainly by the NMR spectroscopic analyses. Bioactivities of the isolated compounds against brine shrimp, yellow fever mosquito larvae, and human tumor cells are reported; compound 4 was the most bioactive, showing selectivity for the human colon tumor cell line (HT-29).
在生物活性导向分离的过程中，从台湾杉全株中分离出两种新的倍半萜，10α-羟基阿莫烷-4-烯-3-酮（1）和4α-甲基杜松烷-4α-甲基-1α,2α,10α-三醇（2），以及四种已知化合物，倍半萜10α-羟基杜松烷-4-烯-3-酮（3）和α-杜松醇（4）、二萜铁锈醇和木脂素日黄草素。化合物1和2的结构主要通过核磁共振光谱分析得以阐明。本文报道了分离得到的化合物对卤虫、黄热病蚊幼虫和人类肿瘤细胞的生物活性；化合物4的生物活性最强，对人结肠肿瘤细胞系（HT-29）具有选择性。
