Uchida Ryuji, Imasato Rie, Yamaguchi Yuichi, Masuma Rokuro, Shiomi Kazuro, Tomoda Hiroshi, Omura Satoshi
School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
J Antibiot (Tokyo). 2006 Oct;59(10):646-51. doi: 10.1038/ja.2006.86.
New nine insecticidal antibiotics designated yaequinolones were isolated from the culture broth of the fungal strain Penicillium sp. FKI-2140 by solvent extraction, centrifugal partition chromatography and HPLC. Yaequinolones showed growth inhibitory activity against brine shrimp (Artemia salina). Among them, yaequinolone F has the most potent activity with MIC value of 0.19 microg/ml.
通过溶剂萃取、离心分配色谱法和高效液相色谱法，从真菌菌株青霉菌FKI - 2140的培养液中分离出九种新的杀虫抗生素，即yaequinolones。Yaequinolones对卤虫（Artemia salina）表现出生长抑制活性。其中，yaequinolone F活性最强，最低抑菌浓度（MIC）值为0.19微克/毫升。
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