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矢车菊诺酮类,由青霉菌FKI-2140产生的新型杀虫抗生素。I. 分类学、发酵、分离及生物活性。

Yaequinolones, new insecticidal antibiotics produced by Penicillium sp. FKI-2140. I. Taxonomy, fermentation, isolation and biological activity.

作者信息

Uchida Ryuji, Imasato Rie, Yamaguchi Yuichi, Masuma Rokuro, Shiomi Kazuro, Tomoda Hiroshi, Omura Satoshi

机构信息

School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

出版信息

J Antibiot (Tokyo). 2006 Oct;59(10):646-51. doi: 10.1038/ja.2006.86.

Abstract

New nine insecticidal antibiotics designated yaequinolones were isolated from the culture broth of the fungal strain Penicillium sp. FKI-2140 by solvent extraction, centrifugal partition chromatography and HPLC. Yaequinolones showed growth inhibitory activity against brine shrimp (Artemia salina). Among them, yaequinolone F has the most potent activity with MIC value of 0.19 microg/ml.

摘要

通过溶剂萃取、离心分配色谱法和高效液相色谱法,从真菌菌株青霉菌FKI - 2140的培养液中分离出九种新的杀虫抗生素,即yaequinolones。Yaequinolones对卤虫(Artemia salina)表现出生长抑制活性。其中,yaequinolone F活性最强,最低抑菌浓度(MIC)值为0.19微克/毫升。

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