Genoketides A1和A2，链霉菌属AK 671产生的新八酮化合物及大黄酚的生物合成中间体。

Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp. AK 671.

作者信息

Fiedler Hans-Peter, Dieter Anke, Gulder Tobias A M, Kajahn Inga, Hamm Andreas, Brown Ros, Jones Amanda L, Goodfellow Michael, Müller Werner E G, Bringmann Gerhard

机构信息

Mikrobiologisches Institut, Universität Tübingen, Tübingen, Germany.

出版信息

J Antibiot (Tokyo). 2008 Jul;61(7):464-73. doi: 10.1038/ja.2008.63.

DOI:10.1038/ja.2008.63

PMID:18776659

Abstract

The new aromatic polyketides genoketide A1, genoketide A2 and prechrysophanol glucuronide are biosynthetic intermediates of the octaketide chrysophanol. They were isolated from the alkaliphilic strain Streptomyces sp. AK 671 together with the new metabolite chrysophanol glucuronide. The structures of the compounds were elucidated by mass spectrometry and NMR methods. Genoketide A2 exhibited a slight and prechrysophanol glucuronide a more pronounced inhibition of the proliferation of L5178y lymphoma cells.

摘要

新型芳香族聚酮化合物genoketide A1、genoketide A2和前大黄酚葡糖苷酸是八酮化合物大黄酚的生物合成中间体。它们是从嗜碱菌株链霉菌属AK 671中分离出来的，同时还分离出了新的代谢产物大黄酚葡糖苷酸。通过质谱和核磁共振方法阐明了这些化合物的结构。Genoketide A2对L5178y淋巴瘤细胞的增殖有轻微抑制作用，而前大黄酚葡糖苷酸的抑制作用更明显。