沙糖多孢菌AJ9571产生的新型细胞毒性20元大环内酯类化合物氨莫西丁B、C和D。
Ammocidins B, C and D, new cytotoxic 20-membered macrolides from Saccharothrix sp. AJ9571.
作者信息
Murakami Ryo, Shinozaki Junko, Kajiura Takayuki, Kozone Ikuko, Takagi Motoki, Shin-Ya Kazuo, Seto Haruo, Hayakawa Yoichi
机构信息
Exploratory Research Laboratories II, Daiichi-Sankyo Co., Ltd, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 2009 Mar;62(3):123-7. doi: 10.1038/ja.2008.23. Epub 2009 Jan 30.
PMID:19198629
Abstract
Ammocidins B, C and D were isolated from the culture broth of Saccharothrix sp. AJ9571, an ammocidin A-producing strain. Their structures were determined by a detailed spectroscopic analysis and by a comparison of their NMR data with those of ammocidin A. Ammocidins A and B showed potent anti-proliferative activities against human cancer cell lines.
摘要
氨莫西丁B、C和D是从产氨莫西丁A的菌株糖丝菌属AJ9571的培养液中分离得到的。通过详细的光谱分析以及将它们的核磁共振数据与氨莫西丁A的数据进行比较来确定其结构。氨莫西丁A和B对人癌细胞系显示出强大的抗增殖活性。
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