新型大环内酯类抗生素舒里霉素A和B的结构研究

Structural studies of new macrolide antibiotics, shurimycins A and B.

作者信息

Kumazawa S, Asami Y, Awane K, Ohtani H, Fukuchi C, Mikawa T, Hayase T

机构信息

Research Center, Mitsubishi Kasei Corporation, Yokohama, Japan.

出版信息

J Antibiot (Tokyo). 1994 Jun;47(6):688-96. doi: 10.7164/antibiotics.47.688.

DOI:10.7164/antibiotics.47.688

PMID:8040074

Abstract

The structures of new antibiotics, shurimycins A and B produced by Streptomyces hygroscopicus A1491, were elucidated from the physico-chemical properties, 2D NMR techniques and chemical degradation experiments to be 36-membered macrolides related to azalomycins, scopafungin and guanidylfungins. Shurimycins were active against fungi and Gram-positive bacteria.

摘要

从吸水链霉菌A1491产生的新抗生素舒里霉素A和B的物理化学性质、二维核磁共振技术及化学降解实验推断，其结构为与氮杂霉素、帚曲霉素和胍基曲霉素相关的36元大环内酯类化合物。舒里霉素对真菌和革兰氏阳性菌具有活性。