血清素与白色念珠菌的相互作用在体外选择性地减弱真菌毒力。
Interaction of serotonin with Candida albicans selectively attenuates fungal virulence in vitro.
作者信息
Mayr A, Hinterberger G, Dierich M P, Lass-Flörl C
机构信息
Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Austria.
出版信息
Int J Antimicrob Agents. 2005 Oct;26(4):335-7. doi: 10.1016/j.ijantimicag.2005.07.006.
Abstract
In this study we investigated whether the direct interaction between Candida albicans CBS 5982 and 5-hydroxytryptamine (5-HT) alters candidial virulence. Hyphae elongation, phospholipase activity and the production of secreted aspartyl proteinases (Saps) following 5-HT treatment were investigated. 5-HT treatment of C. albicans significantly (P < 0.05) affected hyphal extension, phospholipase activity and the production of Saps at concentrations of 118-0.46 mM. In conclusion, our findings suggest that the interaction between 5-HT and C. albicans may diminish the virulence properties of this fungal pathogen.
摘要
在本研究中，我们调查了白色念珠菌CBS 5982与5-羟色胺（5-HT）之间的直接相互作用是否会改变念珠菌的毒力。我们研究了5-HT处理后菌丝伸长、磷脂酶活性以及分泌天冬氨酸蛋白酶（Saps）的产生情况。用5-HT处理白色念珠菌时，在浓度为118 - 0.46 mM时，显著（P < 0.05）影响了菌丝延伸、磷脂酶活性和Saps的产生。总之，我们的研究结果表明，5-HT与白色念珠菌之间的相互作用可能会降低这种真菌病原体的毒力特性。
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