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Antifungal properties of 5-hydroxytryptamine (serotonin) against Candida species in vitro.5-羟色胺（血清素）对念珠菌属的体外抗真菌特性
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Potential role of phospholipases in virulence and fungal pathogenesis.磷脂酶在毒力和真菌致病机制中的潜在作用。
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In vivo expression and localization of Candida albicans secreted aspartyl proteinases during oral candidiasis in HIV-infected patients.白色念珠菌分泌天冬氨酸蛋白酶在HIV感染患者口腔念珠菌病中的体内表达及定位
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Invasive aspergillosis.侵袭性曲霉病
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Human immunodeficiency virus type 1 gp160 and gp41 binding to Candida albicans selectively enhances candidal virulence in vitro.1型人类免疫缺陷病毒糖蛋白160和糖蛋白41与白色念珠菌的结合在体外选择性增强念珠菌的毒力。
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Increased expression of Candida albicans secretory proteinase, a putative virulence factor, in isolates from human immunodeficiency virus-positive patients.白色念珠菌分泌蛋白酶（一种假定的毒力因子）在人类免疫缺陷病毒阳性患者分离株中的表达增加。
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Serotonergic 5-HT1A receptors regulate a cell contact-mediated interaction between natural killer cells and monocytes.
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Candida albicans secreted aspartyl proteinases: isoenzyme pattern is determined by cell type, and levels are determined by environmental factors.白色念珠菌分泌的天冬氨酸蛋白酶：同工酶模式由细胞类型决定，其水平由环境因素决定。
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血清素与白色念珠菌的相互作用在体外选择性地减弱真菌毒力。

Interaction of serotonin with Candida albicans selectively attenuates fungal virulence in vitro.

作者信息

Mayr A, Hinterberger G, Dierich M P, Lass-Flörl C

机构信息

Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Austria.

出版信息

Int J Antimicrob Agents. 2005 Oct;26(4):335-7. doi: 10.1016/j.ijantimicag.2005.07.006.

DOI:10.1016/j.ijantimicag.2005.07.006
PMID:16157477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2980867/
Abstract

In this study we investigated whether the direct interaction between Candida albicans CBS 5982 and 5-hydroxytryptamine (5-HT) alters candidial virulence. Hyphae elongation, phospholipase activity and the production of secreted aspartyl proteinases (Saps) following 5-HT treatment were investigated. 5-HT treatment of C. albicans significantly (P < 0.05) affected hyphal extension, phospholipase activity and the production of Saps at concentrations of 118-0.46 mM. In conclusion, our findings suggest that the interaction between 5-HT and C. albicans may diminish the virulence properties of this fungal pathogen.

摘要

在本研究中，我们调查了白色念珠菌CBS 5982与5-羟色胺（5-HT）之间的直接相互作用是否会改变念珠菌的毒力。我们研究了5-HT处理后菌丝伸长、磷脂酶活性以及分泌天冬氨酸蛋白酶（Saps）的产生情况。用5-HT处理白色念珠菌时，在浓度为118 - 0.46 mM时，显著（P < 0.05）影响了菌丝延伸、磷脂酶活性和Saps的产生。总之，我们的研究结果表明，5-HT与白色念珠菌之间的相互作用可能会降低这种真菌病原体的毒力特性。