5-羟色胺（血清素）与曲霉属在体外的相互作用。

Interaction of 5-hydroxytryptamine (serotonin) against Aspergillus spp. in vitro.

作者信息

Perkhofer Susanne, Niederegger Harald, Blum Gerhard, Burgstaller Wolfgang, Ledochowski Maximilian, Dierich Manfred P, Lass-Flörl Cornelia

机构信息

Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Austria.

出版信息

Int J Antimicrob Agents. 2007 Apr;29(4):424-9. doi: 10.1016/j.ijantimicag.2006.12.003. Epub 2007 Feb 2.

DOI:10.1016/j.ijantimicag.2006.12.003

PMID:17276041

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3010239/

Abstract

This study examined the direct interaction of serotonin (5-hydroxytryptamine (5-HT)) with Aspergillus species. Accumulation of 5-HT in aspergilli was investigated by immunofluorescence staining and laser confocal scanning microscopy. The influence of 5-HT on fungal ergosterol content, cell membrane integrity, fungal growth and hyphal elongation was determined. 5-HT was localised in the cytoplasm of Aspergillus spp., as 5-HT fluorescent signals appeared after 30min at 4 degrees C and in the presence of inhibitors of oxidative phosphorylation. 5-HT treatment of Aspergillus spp. significantly affected ergosterol synthesis, fungal cell membrane integrity and hyphal elongation (P<0.05). 5-HT treatment for 4h resulted in a lag of re-growth (post-antifungal effect). In conclusion, our findings suggest that 5-HT affects hyphal growth and diminishes fungal cell membrane integrity.

摘要

本研究检测了血清素（5-羟色胺（5-HT））与曲霉菌种的直接相互作用。通过免疫荧光染色和激光共聚焦扫描显微镜研究了曲霉菌中5-HT的积累情况。测定了5-HT对真菌麦角固醇含量、细胞膜完整性、真菌生长和菌丝伸长的影响。5-HT定位于曲霉菌种的细胞质中，因为在4℃下30分钟后以及存在氧化磷酸化抑制剂的情况下出现了5-HT荧光信号。用5-HT处理曲霉菌种显著影响麦角固醇合成、真菌细胞膜完整性和菌丝伸长（P<0.05）。用5-HT处理4小时导致再生长滞后（抗真菌后效应）。总之，我们的研究结果表明5-HT影响菌丝生长并降低真菌细胞膜完整性。

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5-羟色胺（血清素）与曲霉属在体外的相互作用。

Interaction of 5-hydroxytryptamine (serotonin) against Aspergillus spp. in vitro.

作者信息

Perkhofer Susanne, Niederegger Harald, Blum Gerhard, Burgstaller Wolfgang, Ledochowski Maximilian, Dierich Manfred P, Lass-Flörl Cornelia

机构信息

Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Austria.

出版信息

Int J Antimicrob Agents. 2007 Apr;29(4):424-9. doi: 10.1016/j.ijantimicag.2006.12.003. Epub 2007 Feb 2.

DOI:10.1016/j.ijantimicag.2006.12.003

PMID:17276041

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3010239/

Abstract

摘要

5-羟色胺（血清素）与曲霉属在体外的相互作用。

Interaction of 5-hydroxytryptamine (serotonin) against Aspergillus spp. in vitro.

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5-羟色胺（血清素）与曲霉属在体外的相互作用。

Interaction of 5-hydroxytryptamine (serotonin) against Aspergillus spp. in vitro.

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出版信息

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