Murata K, Egami H, Shibata Y, Sakamoto K, Misumi A, Ogawa M
Department of Surgery II, Kumamoto University Medical School, Japan.
Am J Clin Pathol. 1992 Jul;98(1):67-75. doi: 10.1093/ajcp/98.1.67.
The expression of blood group-related antigens, A, B, H type 2, Lewis type 1 (Lewis(a) [Le(a)] and Lewis(b) [Le(b)]), Lewis type 2 (Lewis(x) [Le(x)] and Lewis(y) [Le(y)]), sialylated Le(a) (CA19-9), and sialylated Le(x) (CSLEX1), was analyzed sequentially with immunohistochemical methods in early gastric cancer, intestinal metaplasia, and uninvolved gastric mucosa obtained from 35 surgical specimens of patients who underwent gastrectomy. The high incidence of the inappropriate expression of Lewis type 1 antigens and the deletion of H and Lewis type 2 antigens was observed similarly in patients with cancer and intestinal metaplasia. The acquisition of CA19-9 and CSLEX1 and the deletion of B antigen frequently were found in intestinal-type cancer and all types of intestinal metaplasia. The simultaneous deletion of A antigen was detected only in the combination of intestinal-type cancer and incomplete-type intestinal metaplasia. Thus the present study shows that similar changes of tissue antigenicities exist in early gastric cancer and intestinal metaplasia.
采用免疫组织化学方法，对35例接受胃切除术患者的手术标本所获取的早期胃癌、肠化生及未受累胃黏膜中血型相关抗原A、B、H2型、Lewis1型（Lewis(a) [Le(a)]和Lewis(b) [Le(b)]）、Lewis2型（Lewis(x) [Le(x)]和Lewis(y) [Le(y)]）、唾液酸化Le(a)（CA19-9）和唾液酸化Le(x)（CSLEX1）的表达进行了连续分析。在癌症患者和肠化生患者中，同样观察到Lewis1型抗原表达异常以及H和Lewis2型抗原缺失的高发生率。在肠型癌和所有类型的肠化生中，经常发现CA19-9和CSLEX1的获得以及B抗原的缺失。仅在肠型癌和不完全型肠化生的组合中检测到A抗原同时缺失。因此，本研究表明早期胃癌和肠化生中存在相似的组织抗原性变化。
