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铜绿假单胞菌生长的转录组分析:浮游培养物、发育中和成熟生物膜中基因表达的比较

Transcriptome analysis of Pseudomonas aeruginosa growth: comparison of gene expression in planktonic cultures and developing and mature biofilms.

作者信息

Waite Richard D, Papakonstantinopoulou Anastasia, Littler Eddie, Curtis Michael A

机构信息

MRC Molecular Pathogenesis Research Unit, Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and the London, Queen Mary School of Medicine and Dentistry, 4 Newark Street, London, E1 2AT, United Kingdom.

出版信息

J Bacteriol. 2005 Sep;187(18):6571-6. doi: 10.1128/JB.187.18.6571-6576.2005.

Abstract

The transcriptomes of logarithmic- and stationary-phase Pseudomonas aeruginosa planktonic cultures and static biofilms of different stages of development were compared. Developing and confluent biofilm transcriptomes were found to be related to those of logarithmic- and stationary-phase planktonic cultures, respectively. In addition, a number of novel genes were up-regulated in developing and confluent biofilms, including genes encoding putative solute transport proteins and transcriptional regulators, respectively.

摘要

比较了对数期和稳定期铜绿假单胞菌浮游培养物以及不同发育阶段静态生物膜的转录组。发现发育中的生物膜转录组和汇合生物膜转录组分别与对数期和稳定期浮游培养物的转录组相关。此外,一些新基因在发育中的生物膜和汇合生物膜中上调,分别包括编码假定溶质转运蛋白和转录调节因子的基因。

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