Drenkard Eliana
Department of Genetics, Harvard Medical School, Boston, MA 02114, USA.
Microbes Infect. 2003 Nov;5(13):1213-9. doi: 10.1016/j.micinf.2003.08.009.
Resistance to antimicrobial agents is the most important feature of biofilm infections. As a result, infections caused by bacterial biofilms are persistent and very difficult to eradicate. Although several mechanisms have been postulated to explain reduced susceptibility to antimicrobials in bacterial biofilms, it is becoming evident that biofilm resistance is multifactorial. The contribution of each of the different mechanisms involved in biofilm resistance is now beginning to emerge.
对抗菌药物的耐药性是生物膜感染最重要的特征。因此，由细菌生物膜引起的感染持续存在且极难根除。尽管已经提出了几种机制来解释细菌生物膜对抗菌药物敏感性降低的原因，但越来越明显的是，生物膜耐药性是多因素的。现在，参与生物膜耐药性的每种不同机制的作用正开始显现出来。
